Principal Scientist - CADD

San Diego, CA, United States

Hybrid

About the role:

This vital Computer-Aided Drug Discovery (CADD) role, located at our San Diego, CA site, will join our talented and innovative drug discovery team. At Novartis, we value your ideas, personal growth and career aspirations. You will have opportunities to explore the power of cutting-edge science and technology in an environment that truly values multidisciplinary collaborations.

Your key responsibilities:

• Leverage your CADD expertise to engage and influence multidisciplinary project teams for effective decision-making from target identification through candidate nomination

• Drive compound optimization cycles by participation in rational drug design and synthesis prioritization efforts via advanced scoring methods (active learning and ML model development, free-energy perturbation or alternate scoring method), in multi-objective fashion

• Develop, improve and implement efficient computational workflows that can be distributed to our global CADD team

• Initiate drug discovery efforts by proposing novel targets / modalities, evaluating target druggability and executing in silico hit generation, triage and expansion methodologies

• Keep abreast of scientific developments and interact with internal and external scientists to integrate novel insights into computational approaches for drug discovery

Diversity & Inclusion / EEO We are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please let us know the nature of your request, your contact information and the job requisition number in your message:

Novartis: e-mail [email protected] or call +1 (877)395-2339

Sandoz: e-mail [email protected] or call: +1-609-422-4098

Role Requirements • PhD in computational chemistry, computational biology, computational chemical biology, or related field

• 1+ year of experience applying computational methods to drug discovery and small molecule design as a member of therapeutic project teams

• Expert proficiency in one or more commercial drug discovery platform such as ICM, Schrödinger, CCG and/or OpenEye

• Expertise in medicinal chemistry principles, cheminformatics, ADME, ML/AI and structure-based drug discovery

• Demonstrate excellent interpersonal, organizational and communication (written and verbal) skills

Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture

You’ll receive:

You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook.

https://www.novartis.com/careers/benefits-rewards

Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams’ representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $144,000 - $216,000/year; however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Join our Novartis Network: If this role is not suitable to you, but you wish to stay connected to learn more about Novartis and our career opportunities,

join the Novartis Network here: https://talentnetwork.novartis.com/network

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network

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