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AstraZeneca GmbH
New Haven, CT, United States
This is what you will do: Scientist I is responsible for developing, characterizing and supporting technology transfer of robust drug substance manufacturing processes for biologics. The ideal candidate will have in-depth of knowledge of principles and theories of cell line development, medium and feed development, cell culture processes, or bi
Job Source: AstraZeneca GmbHBioCT Innovation Commons
New Haven, CT, United States
This is what you will do: Scientist I is responsible for developing, characterizing and supporting technology transfer of robust drug substance manufacturing processes for biologics. The ideal candidate will have in-depth of knowledge of principles and theories of cell line development, medium and feed development, cell culture processes, or bi
Job Source: BioCT Innovation CommonsAstraZeneca GmbH
New Haven, CT, United States
This is what you will do: The Associate Scientist II is responsible for performing assigned experimental tasks to support the development and optimization of manufacturing processes for Alexion’s biotherapeutic candidates. The Associate Scientist II will work routinely in collaboration with other members of Biologics Process Development, Technology
Job Source: AstraZeneca GmbHBioCT Innovation Commons
New Haven, CT, United States
This is what you will do: The Scientist I is responsible for leading and executing efforts for downstream process development for diverse biotherapeutics to support pre-clinical, early, and late-stage clinical studies. This position is expected to require minimum 70% of the time conducting in-laboratory studies. The ideal candidate will have in-dep
Job Source: BioCT Innovation CommonsAstraZeneca GmbH
New Haven, CT, United States
This is what you will do: Alexion’s Product Development and Clinical Supply (PDCS) organization is seeking a synthetic organic chemist with expertise in flow chemistry, to serve as a subject matter expert with a substantial in-laboratory presence as we build our capability in drug substance continuous manufacturing. The Principal Scientist, Synthet
Job Source: AstraZeneca GmbHAstraZeneca GmbH
New Haven, CT, United States
This is what you will do: Lead cross-functional efforts in the research, design and execution of scientific studies to enable the drug product (DP) formulation and process development, characterization, commercial validation and regulatory filing of parenteral/injectable biologic products. Lead the development of early and late stage formulation de
Job Source: AstraZeneca GmbHQuantum-Si Incorporated
Branford, CT, United States
As a member of the Reagent Development Team, you will be leading the effort in developing novel bioconjugation reactions on peptides from protein digests. Your innovation will be incorporated into the library prep workflow of Quantum-Si's ground-breaking single-molecule protein sequencing platform. As part of our team, your core responsibilities w
Job Source: Quantum-Si IncorporatedQuantum-Si Incorporated
Branford, CT, United States
As a Scientist III specializing in Biochemistry, you'll engage with intricate world of protein/enzyme systems. Your role will be pivotal in the development, optimization, and troubleshooting of protein reagents crucial to our cutting-edge sequencing technology. Expect to establish the downstream process for multiple classes of engineered proteins a
Job Source: Quantum-Si IncorporatedNew Haven, CT, United States
This is what you will do:
The Associate Scientist III is responsible for performing assigned experimental tasks to support the development and optimization of cell line development and cell culture processes for Alexion’s therapeutic protein candidates. The Associate Scientist III will work in collaboration with other members of Product Development and Clinical Supply, and with scientific staff in other Research & Development groups as well as Manufacturing, Quality Assurance and Quality Control groups. The Associate Scientist III will support and executedevelopment studies for biologics lifecycle management and yield improvement with use of process intensification.
You will be responsible for:
Design and execution of experimental studies to generate stable production cell lines for therapeutic protein candidates under supervision
Analyzing data, developing process models, and present scientific findings in support of clone selection and upstream process development
Design and execute experimental studies to develop, optimize, and characterize upstream processes for therapeutic protein candidates under supervision
Executes experimental studies to support scale up of processes at pilot scale
Document study results in notebooks, and technical reports
Coordinate laboratory management including ordering and maintenance
Communicate scientific findings to colleagues within the group through informal presentations
You will need to have:
A successful candidate will typically hold a BS in Chemistry/Chemical Engineering/Biological Sciences or related fields with at least 4 years of experience, or MS with at least 2 years of experience in biotechnology/pharmaceutical industry.
Extensive experience on cell line engineering or cell culture process development activities including drafting technical reports and data analysis is required.
Proficiency with various MS Office programs, including Word, Excel, Outlook, and PowerPoint is required.
The duties of this role are generally conducted in an lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.
We would prefer for you to have:
Extensive knowledge of cell line engineering/development/automation, upstream process development and characterization, is preferred.
Experience developing first-principles model and applying modern ML techniques (i.e. PINNs, neural ODEs, etc.) to develop hybrid models is preferred.
Familarity with multivariate statistical analysis and machine learning fundamentals is preferred.
Proficiency with DoE and statistical analysis software (i.e. Design Expert, JMP, Minitab, or MODDE) is preferred.
Proficiency with objected-oriented or functional programming languages (i.e. Python, Julia, R) and database essentials is preferred.
Experience with one or more modeling software platforms (i.e Pyomo, Modelica, gPROMs) is preferred.
AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
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Email Alert for Associate Scientist III, Upstream Process Development jobs in New Haven, CT, United States
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