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AstraZeneca GmbH
New Haven, CT, United States
This is what you will do: Scientist I is responsible for developing, characterizing and supporting technology transfer of robust drug substance manufacturing processes for biologics. The ideal candidate will have in-depth of knowledge of principles and theories of cell line development, medium and feed development, cell culture processes, or bi
Job Source: AstraZeneca GmbHBioCT Innovation Commons
New Haven, CT, United States
This is what you will do: The Associate Scientist III is responsible for performing assigned experimental tasks to support the development and optimization of cell line development and cell culture processes for Alexion’s therapeutic protein candidates. The Associate Scientist III will work in collaboration with other members of Product Development
Job Source: BioCT Innovation CommonsBioCT Innovation Commons
New Haven, CT, United States
This is what you will do: The Scientist I is responsible for leading and executing efforts for downstream process development for diverse biotherapeutics to support pre-clinical, early, and late-stage clinical studies. This position is expected to require minimum 70% of the time conducting in-laboratory studies. The ideal candidate will have in-dep
Job Source: BioCT Innovation CommonsAstraZeneca GmbH
New Haven, CT, United States
This is what you will do: Alexion’s Product Development and Clinical Supply (PDCS) organization is seeking a synthetic organic chemist with expertise in flow chemistry, to serve as a subject matter expert with a substantial in-laboratory presence as we build our capability in drug substance continuous manufacturing. The Principal Scientist, Synthet
Job Source: AstraZeneca GmbHAstraZeneca GmbH
New Haven, CT, United States
This is what you will do: The Associate Scientist II is responsible for performing assigned experimental tasks to support the development and optimization of manufacturing processes for Alexion’s biotherapeutic candidates. The Associate Scientist II will work routinely in collaboration with other members of Biologics Process Development, Technology
Job Source: AstraZeneca GmbHDetect Inc
Guilford, CT, United States
Company Description Detect’s mission is to make accurate diagnostics accessible. We build breakthrough technology at the intersection of software, hardware, chemistry, and biology to make diagnostics available at the point of need. Our ultimate goal is to lower healthcare costs, improve patient outcomes, and improve doctor experience by enabling ea
Job Source: Detect IncYale NewHaven Health
New Haven, CT, United States
Overview To be part of our organization, every employee should understand and share in the YNHHS Vision, support our Mission, and live our Values. These values - integrity, patient-centered, respect, accountability, and compassion - must guide what we do, as individuals and professionals, every day. The Chief Development Scientist will supervise
Job Source: Yale NewHaven HealthAmphenol TCS
Hamden, CT, United States
Position: Process Development Engineering Manager Location: Hamden, CT Amphenol Spectra-Strip is enabling the electronics revolution with wire and cable solutions. We are the market leader for products that power the internet, cloud compute and artificial intelligence. We make components that run at 224Gbps per lane and can download 100 full leng
Job Source: Amphenol TCSNew Haven, CT, United States
This is what you will do:
Scientist I is responsible for developing, characterizing and supporting technology transfer of robust drug substance manufacturing processes for biologics. The ideal candidate will have in-depth of knowledge of principles and theories of cell line development, medium and feed development, cell culture processes, or bioseparations including chromatography, filtration, and precipitation. The candidate is expected to perform detailed scientific research, execute experiments, analyze experimental data, and provide recommendations to improve efficiency of drug substance man u factu r ing. Beyond proces s development for pipeline molecules, the candidate will support the development of next generation biomanufacturing capabilities through process intensification and continuous manufacturing.
You will be responsible for:
Develop and optimize robust and scalable drug substance manufacturing processes (upstream and downstream) for GMP manufacturing of biologics for clinical and commercial supply
Lead evaluation of next generation manufacturing process throug h to improve the efficiency and cost effectiveness for current work flow
Lead process scale up evaluation and support process tech transfer
Lead small-scale model qualification and process characterization studies
Author internal technical protocols and reports which may have strong interface with other technical functions, regulatory, and compliance
Serve as subject matter expert for cell line/upstream/downstream processes across Alexion internal and external manufacturing network for clinical and commercial processes
You will need to have:
A PhD in Biology/Chemistry/Chemical Engineering/Biological Sciences or related fields, MS with at least 8 years of experience, or BS with at least 10 years of experience in biotechnology/pharmaceutical industry
T echnical knowledge of cell line, upstream, or downstream process development for biologics
S cientific principles and concepts in the field of process development
T echnical proficiency, scientific creativity, learning agility, and ability to collaborate with others
The ability to troubleshoot small and large scale equipment used in upstream/purification processes in area of expertise, and to offer solutions is expected
Strong ability lead cross functional teams
The duties of this role are generally conducted in a lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/ degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.
We would prefer for you to have:
Experience in ATF/TFF perfusion system, process intensification or continuous bio manufacturing
Experience in Process Analytical Technology (PAT) such as Raman
Experience in molecular biology, medium and feed development , aseptic techniques and bioreactor operation
Knowledge and use of statistical analysis, multivariate data analysis and DOE
E xperience in writing and reviewing process-related documents
Strong verbal and written communication and interpersonal skills
Strong a bility for people management
AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
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Email Alert for Scientist I, Upstream Process Development jobs in New Haven, CT, United States
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